పాల్మిటోయ్లేథనోలమైడ్ (పిఇఎ) పౌడర్

ఏప్రిల్ 7, 2020

కాఫ్‌టెక్ చైనాలో అత్యుత్తమ పాల్‌మిటోయ్‌లెథనోలమైడ్ (PEA) పౌడర్ తయారీదారు. మా ఫ్యాక్టరీలో పూర్తి ఉత్పత్తి నిర్వహణ వ్యవస్థ (ISO9001 & ISO14001) ఉంది, నెలవారీ ఉత్పత్తి సామర్థ్యం 3200 కిలోలు.

 


హోదా: మాస్ ప్రొడక్షన్ లో
యూనిట్: 1 కిలో / బ్యాగ్, 25 కిలోలు / డ్రమ్

పాల్మిటోలేథెనోలమైడ్ (పిఇఎ) పౌడర్ (544-31-0) వీడియో

 

పాల్మిటోయ్లేథనోలమైడ్ (పిఇఎ) పౌడర్ Specifications

 

పేరు: పాల్మిటోలేథెనోలమైడ్ (పిఇఎ)
CAS: 544-31-0
స్వచ్ఛత 98% మైక్రోనైజ్డ్ PEA ; 98% పొడి
పరమాణు సూత్రం: C18H37NO2
పరమాణు బరువు: X g / mol
మెల్ట్ పాయింట్: 93 to 98 ° C
రసాయన పేరు: హైడ్రాక్సీథైల్పాల్మిటమైడ్ పామిడ్రోల్ ఎన్-పాల్మిటోలేథెనోలమైన్ పామిటిలేథనోలమైడ్
పర్యాయపదాలు: పాల్మిటోయ్లేథనోలమైడ్

పాల్మిడ్రోల్

N- లో (2-Hydroxyethyl) hexadecanamide

N-palmitoylethanolamine

InChI కీ: HXYVTAGFYLMHSO-UHFFFAOYSA-ఎన్
హాఫ్ లైఫ్: 8 గంటల
ద్రావణీయత: DMSO, మిథనాల్, నీటిలో కరుగుతుంది
నిల్వ పరిస్థితి: స్వల్పకాలికానికి 0 - 4 సి (రోజులు నుండి వారాలు), లేదా -20 సి దీర్ఘకాలిక (నెలలు)
అప్లికేషన్: పాల్మిటోలేథెనోలమైడ్ (పిఇఎ) కొవ్వు ఆమ్లం అమైడ్ల సమూహం ఎండోకన్నబినాయిడ్ కుటుంబానికి చెందినది. PEA అనాల్జేసిక్ మరియు యాంటీ ఇన్ఫ్లమేటరీ కార్యకలాపాలను కలిగి ఉందని నిరూపించబడింది మరియు వివిధ అంతర్లీన క్లినికల్ పరిస్థితులతో వయోజన రోగులలో దీర్ఘకాలిక నొప్పి నిర్వహణపై దృష్టి సారించిన అనేక నియంత్రిత అధ్యయనాలలో ఉపయోగించబడింది.
స్వరూపం: వైట్ పౌడర్

 

పాల్మిటోలేథెనోలమైడ్ (544-31-0) ఎన్ఎంఆర్ స్పెక్ట్రమ్

పాల్మిటోలేథెనోలమైడ్ (544-31-0) - ఎన్‌ఎంఆర్ స్పెక్ట్రమ్

ప్రతి బ్యాచ్ ఉత్పత్తి మరియు ఇతర సమాచారం కోసం మీకు COA, MSDS, HNMR అవసరమైతే, దయచేసి మమ్మల్ని సంప్రదించండి మార్కెటింగ్ మేనేజర్.

 

Palmitoylethanolamide is an endogenic fatty acid amide that falls under the class of Nuclear Factor Agonists. It naturally occurs in foods such as soybean, lecithin peanuts, and the human body.

Palmitoylethanolamide was first discovered in the early 1940s. Scientists first found that consumption of powdered egg yolk promoted a healthy immune response in children and decreased the risk of developing rheumatic fever. Further research concluded that egg yolks contained a special compound i.e., PEA. PEA has also been found in whole foods like peanuts and soybean, which help provide strong immunity and health benefits.

Besides being found in certain foods, PEA is also occurring in our body naturally. The chemical is produced in our body by many of our cells as a part of a healthy immune response. PEA is specially made by our body in response to inflammation. It is known to manage our pain in the body by protecting our immune system from overreacting and it promotes a healthy immune and inflammatory reaction in the body.

Palmitoylethanolamide powder is mostly used as a medicine for pain, fibromyalgia, neuropathic pain, multiple sclerosis, carpal tunnel syndrome, and many other conditions.

 

Palmitoylethanolamide and the Cannabinoid Family

Palmitoylethanolamide does not necessarily come from cannabis but can be considered part of the cannabinoid family. PEA works in a very similar way to CBD (cannabidiol), which is one of the main compounds in cannabis but it doesn’t have psychogenic effects. CBD products are very popular these days and are available in almost everything from oils to creams, and food products. CBD products are also used for many potential health benefits, including mental, nerve, and joint health.

PEA is also a cannabinoid, but it is analyzed as an ఎండోcannabinoid as it is made within the body. However, it is different from cannabidiol and tetrahydrocannabinol as the body does not naturally make these chemicals.

 

మెకానిజం ఆఫ్ యాక్షన్

Palmitoylethanolamide triggers the fat-burning, energy-boosting, and anti-inflammatory PPAR alpha. When these key proteins get activated, PEA stops the action of genes capable of promoting inflammation and reduces the production of several inflammatory substances. PEA also minimizes the activity of the gene FAAH that breaks down natural cannabinoid anandamide and maximizes the levels of anandamide in the body. Anandamide is responsible for decreasing your pain, calming your mind, and promoting relaxation in your body.

PEA is also known to bind to the body cells and reduce pain and swelling. It contains palmitic acid in its structure, which helps the body make Palmitoylethanolamide in the body.

According to some scientists, simply increasing your intake of palmitic acid will not affect PEA production. This is because your body will only utilize PEA in your body only when it needs to heal your inflammation or pain. This results in the levels of PEA in the body normally varying throughout the day.

The best way to get the benefits of PEA is by consuming PEA-rich foods or standardized supplements.

 

Palmitoylethanolamide powder benefits and applications

PEA has been proven to have pain-relieving and anti-inflammatory properties and has been used for the management of chronic pain among adults with multiple underlying clinical conditions. For example, it can provide a helpful effect like adjuvant for the treatment of low back pain in older patients or can be used alone for chronic pain management in critically ill patients in place of traditional analgesics which have a high risk of adverse effects.

Promising results have been demonstrated in the treatment of non-surgical radiculopathies with an ultra-micronized formulation of PEA and the combination therapy with alpha-lipoic acid to reduce chronic prostatitis/chronic pelvic pain syndrome.

Below are some great benefits of PEA:

 

· నొప్పి నివారిని

There is some evidence that validates PEA’s ability to reduce severe pain. PEA has been investigated in over 6 thousand people and 30 clinical trials since the 1070s. However, the study often has failed to differentiate between neuropathic and non-neuropathic pain. The యొక్క ప్రయోజనాలు పాల్మిటోయ్లేథనోలమైడ్ for neuropathic pain are less clear due to less sufficient information to date.

Another restriction was that most of these studies lacked a placebo control and high-quality research is required to decide the effectiveness of PEA in relieving different types of pain.

In a survey of 12 human studies, PEA supplements showed effectiveness in the reduction of chronic and neuropathic pain potency without any serious side effects. Those 12 persons were typically given PEA supplements with dosages between 200 to 1200 mg/day for over 3 to 8 weeks. The supplement took about two weeks to achieve the pain-relieving state. Taking it for any longer period nourished its effects without causing any adverse effects.

Another study performed with 300 or 600 mg/day of PEA showed a strong reduction in sciatica pain in a pivotal trial of over 600 people. PEA reduced pain by over 50% in just 3 weeks, which is hardly achieved with most painkillers.

 

· Brain health and regeneration

PEA has also been known to be beneficial for neurodegenerative diseases and stroke. The supplement is perceived to improve brain function by helping brain cells to survive and lower inflammation.

In a study of 250 stroke patients, a formulation of PEA with luteolin showed signs of improved recovery. It is also proclaimed to have a beneficial effect on good brain health, cognitive skills, and daily brain functioning. The effects were noticeable after 30 days of supplementation and when after two months of supplementation, more improvement was noticed.

Both with luteolin and alone, PEA was seen to prevent Parkinson’s disease in mice when used with luteolin. It reduces the damage in the brain by protecting the dopamine neurons. However, standard clinical studies are needed to verify these findings.

Another study showed that PEA with luteolin helped to enhance the neurotrophic factors like BDNF & NGF which are small powerful proteins useful to create new brain cells. It enhanced the brain’s ability to regenerate new cells and tissues after distressing damage to the spinal cord or brain. When PEA along with luteolin was used in mice it enhanced the healing of nerves in mice with spinal cord injuries.

Due to the natural occurrence of cannabinoids in PEA, the effects showed an enhancement in patients’ behavior, mood. It showed a decreased seizure risk in mice. However, its effects on seizures are yet to be investigated in humans and further studies are needed to verify this.

 

· Effects on the Heart

A heart attack occurs as a result of blockage of blood vessels directing to the heart. PEA is known to recover damage of heart tissues and increase the blood flow to the heart which helps minimize the cases of a heart attack. A study in mice also showed the lowering of inflammatory cytokine levels in hearts.

The use of PEA also diminished the level of high blood pressure in rats and prevented kidney damage by reducing inflammatory substances. By narrowing the blood vessels, PEA was effective to block the enzymes and receptors that increase blood pressure.

 

· నిరాశ సంకేతాలు

In a recent study, 58 people suffering from depression were treated with PEA. Doses of 1.2 gm per day were given to the patients for over 6 weeks. This resulted in rapid improvement of mood and overall symptoms. PEA when added to antidepressant remedy i.e., citalopram, lowered symptoms of depression by a standard 50%.

 

· Symptoms of the common cold

Another study showed PEA to be an effective remedy to fight the influenza virus that causes the common cold. In some early surveys of over 4 thousand people, PEA was able to manifest a positive impact in immunity and helped reduce flu-like symptoms in patients.

In another study, 900 young soldiers were given about 1,200 mg of PEA that lessened the duration of the cold and healed symptoms like sore throat, runny nose, fever, and headaches.

 

· గట్ మంట

Last but not least PEA was successfully used to revive signs of inflammatory bowel disease (IBS) in animals. PEA supplements when tested in mice with chronic gut inflammation, helped normalize the bowel movement and effectively prevented damage to the gut lining.

The gut damage or inflammation is caused by ulcerative colitis which can lead to the risk of cancer. The use of PEA stopped the normal gut tissue from promoting cancerous overgrowth in mice. PEA reduces the inflammatory cytokines and the growth of neutrophils and immune cells that intensifies the symptoms of gut damage.

 

Palmitoylethanolamide food sources

Although PEA is a saturated fatty acid, including more saturated fats in your diet will do more harm than good. Consuming foods high in saturated fats won’t increase your body’s PEA production instead will increase your risk of developing various chronic and inflammatory diseases.

Foods like soy products, soy lecithin, peanuts, and alfalfa are some great sources of PEA. People with nut allergies should necessarily skip peanuts and consume other foods. Egg yolk is another good source and can be consumed by people who don’t have sensitivity to eggs. Consumers can also consider taking PEA supplements as they are a safer and an effective choice.

 

PEA supplements dosage & safety

According to clinical studies, at least 600 mg/day may be required to relieve nerve pain, and doses of 1.2 g/day might be used to treat diabetic nerve pain.

For diabetic patients suffering from eye problems, doses up to 1.8 g/day were effective for reducing damage to the eye nerves.

For the cure of the common cold, 1.2 g/day of PEA was the standard dosage.

Talk to your doctor before taking supplements of PEA as PEA has not been approved by the FDA to take in larger doses.

Consuming Palmitoylethanolamide powder or supplements in small, limited doses is generally considered safe. However, more advanced clinical studies are required for higher doses. Long-term PEA supplementation is also known to be safe according to some small-scale studies.

Certain manufacturers from the PEA manufacturer factory recommend splitting the total dose into two portions and consuming it during the day. In some cases, micronized PEA, which in simple words is fine palmitoylethanolamide powder, is known to be better absorbed in the body and scientists consider the powder form to be superior to other forms.

 

PEA side effects

Oral consumption of palmitoylethanolamide is generally considered safe for most adults when used for up to 3 months. To date, no serious complications or drug-to-drug interaction has been identified. However, there is not enough information to say the drug can be safe when used for longer than three months. Side effects can include an upset stomach, which is very rare.

To be clearer, PEA didn’t cause any serious complications in any of the above studies but it still lacks proper safety studies. Also, there is insufficient evidence to figure the amount of effectiveness of PEA in patients with these types of pain.

 

గర్భం మరియు పిల్లలు

PEA is generally considered safe for the use of adults and a couple of studies have also shown less to no risks in children. But larger studies would need to verify the safety of PEA in children. Due to lack of sufficient clinical data, pregnant and breastfeeding women are suggested to follow a caution and consult a doctor before taking any PEA supplements.

 

ముగింపు

PEA has reduced several adverse effects and pain while improving the quality of life. Its studies support the safety and efficiency of the fatty acid and are recommended safe in the clinical use of PEA. The supplement is most effective for compression syndromes including carpal tunnel syndrome and sciatic pain. PEA supplementation is also easy to take and can be administered orally.

Remember to consult with a doctor before taking any PEA supplements as higher doses of PEA can lead to some complications. Although the complications are majorly mild and not serious, PEA should not be used as a substitute for approved medical therapies. However, the above-described benefits and studies were conducted mostly in animals and cells. The stable clinical evidence is still lacking.

More studies in humans are required to determine the effects of PEA on gut health, heart, and histamine release.

 

Palmitoylethanolamide (PEA) powder for sale&Where to buy Palmitoylethanolamide (PEA) powder in bulk

కస్టమర్ సేవ మరియు గొప్ప ఉత్పత్తులను అందించడంపై మేము దృష్టి కేంద్రీకరించినందున మా కంపెనీ మా ఖాతాదారులతో దీర్ఘకాలిక సంబంధాలను కలిగి ఉంది. మీరు మా ఉత్పత్తిపై ఆసక్తి కలిగి ఉంటే, మీ నిర్దిష్ట అవసరానికి అనుగుణంగా ఆర్డర్‌ల అనుకూలీకరణతో మేము సరళంగా ఉంటాము మరియు ఆర్డర్‌లపై మా శీఘ్ర ప్రధాన సమయం మీకు మా ఉత్పత్తిని సమయానికి రుచి చూస్తుందని హామీ ఇస్తుంది. మేము విలువ ఆధారిత సేవలపై కూడా దృష్టి పెడతాము. మీ వ్యాపారానికి మద్దతు ఇవ్వడానికి మేము సేవా ప్రశ్నలు మరియు సమాచారం కోసం అందుబాటులో ఉన్నాము.

మేము చాలా సంవత్సరాలు ప్రొఫెషనల్ పాల్మిటోలేథెనోలమైడ్ (పిఇఎ) పౌడర్ సరఫరాదారు, మేము పోటీ ధరతో ఉత్పత్తులను సరఫరా చేస్తాము మరియు మా ఉత్పత్తి అత్యధిక నాణ్యతతో ఉంది మరియు ప్రపంచవ్యాప్తంగా వినియోగానికి సురక్షితంగా ఉందని నిర్ధారించడానికి కఠినమైన, స్వతంత్ర పరీక్షలకు లోనవుతుంది.

 

ప్రస్తావనలు

  • హాన్సెన్ హెచ్ఎస్. పాల్మిటోలేథెనోలమైడ్ మరియు ఇతర అనాండమైడ్ కన్జనర్లు. వ్యాధిగ్రస్తులైన మెదడులో ప్రతిపాదిత పాత్ర. ఎక్స్ న్యూరోల్. 2010; 224 (1): 48-55
  • పెట్రోసినో ఎస్, ఐవోన్ టి, డి మార్జో వి. ఎన్-పాల్మిటోయిల్-ఇథనోలమైన్: బయోకెమిస్ట్రీ మరియు కొత్త చికిత్సా అవకాశాలు. Biochimie. 2010; 92 (6): 724-7
  • సెరాటో ఎస్, బ్రజిస్ పి, డెల్లా వల్లే ఎమ్ఎఫ్, మియోలో ఎ, పుయిగ్డెమోంట్ ఎ. రోగనిరోధక ప్రేరిత హిస్టామిన్, పిజిడి 2 మరియు టిఎన్‌ఎఫ్ on పై పల్మిటోయ్లేథనోలమైడ్ యొక్క ప్రభావాలు కనైన్ స్కిన్ మాస్ట్ కణాల నుండి విడుదల. వెట్ ఇమ్యునోల్ ఇమ్యునోపాథోల్. 2010; 133 (1): 9-15
  • పాల్మిటోలేథెనోలమైడ్ (పిఇఎ): ప్రయోజనాలు, మోతాదు, ఉపయోగాలు, అనుబంధం